I've got a buddy who has a 350 in his 2500(same gen truck as yours) and he's got a blackbear tune and in his it make a big difference compared to without, he's also got a cold air intake(k&n) and magnaflow dual in single out, and it doesn't really pop or crackle ever, but if you can do dyno tune it would obviously be way better for it, but being the same gen 350 that's what works good on his