"33's" is a somewhat relative statement. Some weigh quite a bit more than others, as well as the rim. Not sure if it's obvious here, but the heavier they are, the harder they are to get rollin'.
I've got some heavy 305/55/20's and a small ~5" lift, as well as oversize 14" rotors which also add to the rotating mass/unsprung weight, and just went with Motive Performance 4.30's over my factory GT4 3.73's. And I see quite a bit of expressway too, as well as some occasional towing, and the regular hauling of ass.
I almost went with 4.56's, and hope I don't regret changing that decision within the next few months here, as I get used to the 4.30's.
The 4.10's will get you around fine though (all depends on the driver preference/driving style though), with 33's it will probably feel fairly similar to a stocker truck with 31's and 3.73's I would guess, probably a fairly good comparison.