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Tuneup Help Please

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Ok, I've never replace the plugs and wires on a distributorless engine before like the 5.3L vortec I have in my 2k suburban.

What needs to be replaced besides the plugs and wires? I'm guessing iridium plugs and msd wire set?

Thanks for any help! Don't forget to dumb down your response for me! :rolleyes:
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